Brain Death - 3rd Edition by Wijdicks

Oxford University Press has just published the 3rd edition of Brain Death by the leading expert on brain death, Eelco F.M. Wijdicks.

Brain Death provides a practical, comprehensive, clinical resource for practitioners seeing patients with acute catastrophic neurologic disorders evolving to brain death and all its ramifications. The clinical diagnosis of brain death has tremendous implications: its main purpose is to bring closure, but it often results in organ and tissue transplantation questions which need to be addressed.

This third edition introduces new research in the intensive care unit, newly unearthed historical data on important US-UK differences, a thorough discussion of US guidelines and how it is used in hospital practices, and compares guidelines used elsewhere in the world. In this incisive work, the many complexities of diagnosis and management of brain death are examined but it also illuminates cultural beliefs and bioethical problems, highlights the nature of conferences with family members, and captures several organ procurement issues. The book also includes 30 commonly asked practice problems to resolve diagnostic uncertainties and conflicts along with 12 video clips to assist in neurological evaluation.  

Chapter 1: History of Brain Death

A New Comatose State Appears

Defining Neurologic Criteria for Death in Us

Chapter 2: Neurology of Brain Death

The Pathology of Brain Death

Clinical Examination in Adults

The Clinical Determination of Brain Death in Children


Teaching Brain Death Determination

Errors and Alleged Recoveries

Legal Definitions and Obligations

Chapter 3: International Criteria of Brain Death

Guidelines in the United Kingdom

Guidelines World Wide

Consensus for a Uniform World Wide Standard

Chapter 4: Beliefs About Brain Death

Religious Beliefs

Cultural Views

Religious Conflict Resolution

Chapter 5: Critics and Brain Death

The Uncertainty of Death

Emerging Controversies


Chapter 6: Procurement After Brain Death 

Transitioning to Organ Donation

Organ Procurement Organizations

Organ Donation Requests

Preparation for Determining Organ Suitability

Donation Protocols

Medical Management of the Organ Donor

Chapter 7: Clinical Problems in Brain Death and Organ Donation

1. The Qualifications of the Examiner

2. Clinical Mimics

3. Acid-Base Disturbances

4. Electrolyte Abnormalities

5. Acute Intoxications and Overdose

6. Reliability of Ancillary Tests

7. Ancillary Tests and Confounders

8. Primary Brainstem Lesion

9. Uncertainty About Interpreting Spinal Reflexes

10. Ventilator Autocycling

11. Chronic CO2 Retention and Apnea Test

12. Terminating the Apnea Test

13. Breathing during the Apnea Test

14. Pneumothorax during the Apnea Test

15. Cardiopulmonary Resuscitation

16. Extracorporeal Membrane Oxygenation 

17. Anencephaly 

18. Shaken Baby Syndrome

19. Maternal Brain Death

20. Legal Challenges 

21. Family Opposition 

22. Family Presence during Testing

23. Sperm and Oocyte Retrieval 

24. Organ Donation Management

25. Organ Donation and the Hemodynamically Unstable Donor

26. DCD Pitfalls

27. DCD in the Operating Room

28. Organ Donation in Prisoners

29. Organ Donation, Consent and Costs

30. Organ Donation and Directing the Gift

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